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Lack of an association or an inverse association between low-density- lipoprotein cholesterol and mortality in the elderly: a systematic review

http://bmjopen.bmj.com/content/bmjopen/6/6/e010401.full.pdf

Conclusions:
High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly LDL-C, is inherently atherogenic). Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis. Moreover, our study provides the rationale for a re-evaluation of guidelines recommending pharmacological reduction of LDL-C in the elderly as a component of cardiovascular disease prevention strategies.

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